Combinatorial Therapies for Recurrent ER- Breast Cancers
Arpita Guha Neogi1, Harini Subramaniam2
1,2Student, RV College of Engineering, Bengaluru, Karnataka
Corresponding Author: Harini Subramaniam (harinis.bt18@rvce.edu.in)
Introduction:
Cancers are the leading cause of mortality all over the world according to WHO. In this review, we aim to show the use of common Statins to have potential applications in combinatorial therapies. Disorders related to heart and blood vessels including coronary heart disease (interference in blood supply to heart muscles), cerebrovascular heart disease (interference in blood supply to brain), rheumatic heart disease, congenital heart diseases fall under CVDs. These disorders under acute conditions cause angina, strokes and fatal heart attacks, which caused the global death of 85% CVD patients in 2016 [1] [2]. This is related to high levels of cholesterol in plasma, since hypercholesterolemia is a primary risk factor of atherosclerosis and coronary artery disease [3].
Lovastatin is a naturally occurring statin drug, used for lowering cholesterol in those with hypercholesterolemia to reduce risk of cancer [4]. Pure Lovastatin is used in the manufacture of drugs, which is currently very expensive in the present market. The focus of this project is the extraction of statins from fruit and vegetable waste using filamentous fungi as literature survey has shown that these contain a fair amount of Statins. Fruits and vegetable peels being waste products are discarded anyway, and thus using these to extract statins will not only be cost effective but will provide better waste management solutions.
The prevalence of raised total cholesterol increases noticeably according to the income level of a country. In low-income countries around a quarter of adults had raised total cholesterol, in lower middle-income countries this rose to around a third of the population for both sexes. In high-income countries, over 50% of adults had raised total cholesterol; more than double the level of the low-income countries [5].