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Innovative Roll-On Gel Formulation of Miconazole for Enhanced Patient Compliance
Devika Sahu1, Monika Sahu2, Pankaj Patel1, Minakshi Sahu1, Shobha Sahu2, Gyanesh Kumar Sahu2*
1Rungta Institute of Pharmaceutical Sciences
2Rungta Institute of Pharmaceutical Sciences & Research
1. Introduction –
Fungal infections, caused by dermatophytes and yeasts, are a widespread global health concern, particularly in warm, humid environments that favour fungal growth. These infections, commonly affecting the skin, hair, and nails, include conditions like Tinea Pedis (Athlete’s Foot), Tinea Corporis (Ringworm), and Onychomycosis (nail infections). [1,2] While not life-threatening in most cases, these infections can cause significant discomfort, itching, and social embarrassment, impacting the quality of life. Superficial fungal infections are highly contagious and thrive in communal environments like swimming pools, gyms, and locker rooms, making prevention and effective treatment essential. [3,4]
Among antifungal treatments, azole drugs such as clotrimazole, miconazole, and ketoconazole are widely used for their efficacy and safety. These drugs inhibit ergosterol synthesis, a vital component of fungal cell membranes, leading to the disruption of fungal growth. Miconazole, in particular, is known for its broad-spectrum activity against dermatophytes and yeasts. Its availability in various formulations, including creams, powders, and gels, makes it versatile for treating different fungal infections. [5,6] The development of a roll-on gel formulation for miconazole further enhances its utility, offering easy application, targeted delivery, and hygienic use, especially for areas like the feet and groin.
A common broad-spectrum antifungal medication used to treat a variety of mucosal and superficial fungal infections is miconazole. Miconazole, a member of the azole antifungal class, works by preventing the production of ergosterol, which is essential for the formation of fungal cell membranes. Miconazole is a successful treatment for a variety of dermatophyte and yeast infections because it causes fungal cell death through a breakdown in the integrity of the cell membrane. [7,8]
The medication is available in creams, powders, sprays, vaginal suppositories, and oral gels, and its effectiveness is extended to both topical and systemic formulations. Miconazole is a well-liked option for treating mild to moderate fungal infections in outpatient settings due to its accessibility and adaptability. [9,10]
Apart from its well-established medicinal use, miconazole is renowned for having a comparatively low frequency of adverse effects, however skin irritation and, in rare cases, systemic reactions are possible. Due to its safety profile, the medication is now widely used for both clinical treatment of fungal infections and self-care. Despite its wide range of applications, further consideration of its efficacy and use is necessary due to the development of drug resistance in certain fungal strains and the possibility of medication interactions, especially with oral anticoagulants[11,12].