A Review on: Role of Medicinal Plants in Hepatocellular Carcinoma

A Review on: Role of Medicinal Plants in Hepatocellular Carcinoma

Ch. Lochana*¹, B. Vidya Sri*², G. Sudhakar*³, V. Shyamala*⁴, J. Sai Anusha*⁵

*¹ Ch. Lochana, Assistant Professor, Department of Pharmacology, Srinivasa Rao College of Pharmacy

*² B. Vidya Sri, M. Pharmacy Student, Department of Pharmacology, Srinivasa Rao College of Pharmacy

*³ G. Sudhakar, Professor, Department of Pharmacology, Srinivasa Rao College of Pharmacy

*⁴ V. Shyamala, Assistant Professor, Department of Pharmacology, Srinivasa Rao College of Pharmacy

*⁵ J. Sai Anusha, M. Pharmacy Student, Department of Pharmacology, Srinivasa Rao College of Pharmacy

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Abstract

Hepatocellular carcinoma (HCC) is the fifth common tumor worldwide. In the United States, HCC is that the ninth leading cause of cancer deaths. HCC is the primary liver malignancy and could be a leading reason for cancer related death worldwide. Despite advances in prevention techniques, screening, and new technologies in both diagnosis and treatment, incidence and mortality still rise. HCC remains a global health challenge, with an estimated prevalence of >1 million cases by 2025. Multiple treatment options are available for HCC including liver transplantation (LT), radiofrequency ablation (RFA), trans arterial chemoembolization (TAF), radioembolization and systemic targeted agent like sorafenib. The treatment for HCC depends on the tumour stage, patient performance status. Among the past few years with significant advances in surgical treatments and locoregional therapies, the short-term survival of HCC has improved but the recurrent disease remains an enormous problem. Little progress has been made for this cancer, whose mortality is 100 % at 10 years. Progression from infection to cirrhosis takes average 20 years. The present study deals various medicinal plants that have a Pharmacological effect on HCC.

Keywords: Hepatocellular carcinoma, Liver transplantation, Radiofrequency ablation, Trans arterial chemoembolization, Radioembolization, Cirrhotic liver