Green Synthesis of Benzimidazoles: Sustainable Graphene Oxide Catalyst for Bioactive Compound Design and Drug Discovery

Green Synthesis of Benzimidazoles: Sustainable Graphene Oxide Catalyst for Bioactive Compound Design and Drug Discovery

1Premanand Kumar Bhagat, 2Devendra Nath Thakur, 3Rudhima Raj, 4smriti Singh, 5L.K. Mishra,

1,2,5Department of Chemistry ,Patna University, Patna, India , 3,4Department of Chemistry, Ranchi University, Ranchi, Jharkhand, India , Dr. Harisingh Gour University, Sagar, MP, India,

Abstract

We report a novel and eco-friendly method for synthesizing a series of benzimidazoles using 1,3,5-Tris(2-hydroxyethyl) isocyanurate-Cu(II) functionalized magnetic graphene oxide (MGO-THEIC-CuII) as a catalyst under microwave irradiation in ethanol. The newly synthesized compounds were thoroughly characterized by IR and NMR spectroscopy. Furthermore, their biological activities were assessed through antimicrobial activity and Brine-Shrimp lethality assays. The results demonstrate the efficacy and versatility of the developed green synthesis approach, which could have significant implications in the design of bioactive compounds. These findings open new avenues for the development of sustainable and efficient methodologies in drug discovery and related fields.

Keywords: Benzimidazole, Graphene Oxide, Biological Activity