A Research Paper Captopril as a prolonged release matrix tablet: Formulation, Characterization and In-vitro dissolution study

Background: In current situation conventional dosage forms fails in sustaining the release from dosage form lead to fluctuation in dosage and shows peak-valley drug plasma profile. To overcome these problem associated with drug release, need to design such type of dosage form which extend the release with efficacy and to achieve steady state plasma drug conentration. Objective: Design and delivery characteristics of prolonged release matrix tablet of captopril and evaluation was subjected for Swelling Index and In-vitro release of drug from formulation. Material & method: By using HPMC K100, Ethyl cellulose, Xanthan gum, PVP K30, as release retardant polymer, captopril drug and other ingredients were mixed thoroughly and subjected to direct compression method in order to get Sustained release matrix tablet. Total 9 formulations were prepared and subjected for all the necessary evaluation tests. Result: In the preparation of sustained release tablet, pre-compression and post compression parameters found to be within the limit. Among all 9 formulations R-4 formulation was found to optimize in context with physicochemical parameters, swelling index, Drug content, weight variation and in-vitro drug release. Conclusion: Captopril prolonged release matrix tablet were prepared successfully and from the result it can be concluded that unique combination of Xanthan gum and Ethyl cellulose at concentration of 20 % and 15 % respectively produces better dosage form in order to release retardation.