Ayurvedic Management of Refractory Cardiometabolic Syndrome with Polyherbal Formulations: A Case Report

Ayurvedic Management of Refractory Cardiometabolic Syndrome with Polyherbal Formulations: A Case Report

Authors:
Dr. Siddharth Deepak Jadhav (D.Sc. Hons., B.Tech)¹, Dr. Abhijeet Bhandare (D.Sc. Hons., Dietitians & Nutritionists)¹, Dr. Aniket Jadhavar (B.H.M.S.)¹, Dr. Awesh Nemade (B.H.M.S.)¹, Dr. Vinod Kokitkar (M.D. Ayurveda)², Dr. Rajendra Atre (M.D. Medicine)³
Affiliations:
¹ Ayush Sanjivani Herbal Nutrition, Maharashtra, India.

²,³ Consulting Specialists

Corresponding Author:
Dr. Siddharth Deepak Jadhav, (D.Sc. Hons, B.Tech)
Scientific Author, Research Scientist

Ayush Sanjivani Herbal Nutrition, Satara

Maharashtra, India

Email: [ayushsanjivaniherbalnutrition@gmail.com]

Abstract
Background: Cardiometabolic syndrome, a cluster of interrelated conditions, including hypertensive heart disease, non-obstructive hypertrophic, cardiomyopathy; type 2 diabetes mellitus, Hypertension, and bilateral pedal edema. often presents a therapeutic challenge with conventional allopathic polypharmacy. This case report examines the potential of a holistic Ayurvedic protocol in managing a complex, refractory case. After three years of conventional allopathic treatment with suboptimal symptom control, an Ayurvedic intervention was initiated.

Case Presentation: A 77-year-old Indian male with a three-year history of progressively worsening hypertensive heart disease, non-obstructive hypertrophic cardiomyopathy, type 2 diabetes mellitus, Hypertension, and bilateral pedal edema, poorly controlled despite optimal allopathic therapy. A significant deterioration in health status was noted by the patient post-COVID-19 vaccination, though causality cannot be established. The temporal association is noted, though a causal relationship cannot be established from this single case. Despite continuous allopathic care from November 2020 to September 2023, his condition showed progressive deterioration, with worsening hypertension, glycemic control, and recurrent edema.

Intervention: A 28-day intensive Ayurvedic regimen followed by a maintenance protocol was initiated. Focusing on root-cause management of underlying doshic imbalances (Vata-Kapha vitiation with Ama formation).The core intervention comprised two proprietary polyherbal formulations: Ayush Sanjivani Urja (a Rasayana / rejuvenative) and Ayush Sanjivani Madhunashini (for glucose metabolism), alongside dietary and lifestyle modifications. A combination of two Ayurvedic formulations—Ayush Sanjivani Urja (Immunity Booster) capsules and Ayush Sanjivani Madhunashini capsules—were administered over a 28-day intensive phase, followed by a maintenance regimen. Adjunctive lifestyle modifications were advised.

Outcomes: Over six months, dramatic improvements were observed. Blood pressure normalized (160/98 to 123/90 mmHg), glycemic control was achieved (FBS: 163 to 91.10 mg/dL; PPBS: 272 to 120.20 mg/dL; hs-CRP: 4.5 to 0.9 mg/L and HbA1C: 7.5% to 5.0%), and debilitating symptoms like shortness of breath, palpitations, and pedal edema resolved completely. The patient's quality of life improved significantly, and the dosage of allopathic medications was progressively reduced.

Conclusion: This case suggests that the described Ayurvedic protocol may be a potent complementary approach for managing complex, multi-system cardiometabolic diseases refractory to conventional treatment. The results warrant further investigation through controlled clinical trials.

Keywords: Ayurveda, Case Report, Cardiometabolic Syndrome, Hypertrophic Cardiomyopathy, Type 2 Diabetes, Polyherbal Formulation, Integrative Medicine. 1. Introduction

Cardiometabolic syndrome represents a significant global health burden, characterized by the co-occurrence of hypertension, dyslipidemia, insulin resistance, and central obesity. Conventional management often involves polypharmacy, targeting individual pathologies but frequently failing to address the underlying systemic dysfunction and suffering from side effects. Ayurveda, with its holistic framework focusing on restoring Doshic balance (Vata, Pitta, Kapha) and digestive fire (Agni), offers a unique root-cause approach. This report details the successful Ayurvedic management of a severe, refractory case using two novel polyherbal formulations, demonstrating potential for an integrative treatment model.