Conservative Approaches to Intervertebral Disc Prolapse: A Comprehensive Review

Conservative Approaches to Intervertebral Disc Prolapse: A Comprehensive Review

C. Pradeep1*, K. Sravani1, J. Vanitha1, K. Thirumala Naik2

1*, 1,1 – Pharm.D Interns, Krishma Teja Pharmacy College, Tirupati, Andhra Pradesh

2- Associate Professor, Clinical Preceptor, Krishma Teja Pharmacy College, Tirupati, Andhra Pradesh

ABSTRACT

Disc herniation is a common condition involving the protrusion of the nucleus pulposus through the annulus fibrosus, often resulting in nerve root compression and symptoms like sciatica. The vertebral column consists of 33 vertebrae, and the intervertebral discs (IVDs) between them play a crucial role in shock absorption and movement. The incidence of herniated discs is approximately 5-20 cases per 1000 adults annually, with peak occurrence in the 4th and 5th decades of life. Risk factors include genetic predisposition, high BMI, smoking, aging, physical labor, and spine injury. The pathophysiology of disc herniation involves the degeneration of disc structures, with the annulus fibrosus and nucleus pulposus contributing to biomechanical function. Herniation typically occurs posterolaterally and is most common at the L4/L5 and L5/S1 levels. Diagnostic tools such as X-rays, CT scans, and MRI are essential in confirming disc herniation and nerve root compression. Conservative management, including physical therapy, pharmacological treatment, and corticosteroid injections, is the first-line treatment for most patients. While conservative therapy has a lower risk of complications and is generally effective, a subset of patients may not achieve lasting relief and require surgical intervention. Understanding the epidemiology, pathophysiology, and management strategies for disc herniation is crucial for improving patient outcomes.

Keywords: Disc herniation, intervertebral disc, sciatica, conservative treatment, MRI, physical therapy, epidural injections, pathophysiology, lumbar spine, nerve root compression