Hydrogel-Based Hydrophilic Polymers for Controlled Release and Bioavailability Enhancement

Hydrogel-Based Hydrophilic Polymers for Controlled Release and Bioavailability Enhancement

Ujjawal Dubey1, Sakshi Soni1, Rishu Kumar1, Anjali Sahu1, Gyanesh Kumar Sahu1

1Rungta Institute of Pharmaceutical Sciences & Research

ABSTRACT

The unique characteristics they possess, such as their high-water retention, biocompatibility, and capacity to expand in aquatic conditions, hydrogels—three-dimensional networks of hydrophilic polymers—have become extremely useful materials in the pharmaceutical industry. Because of these properties, hydrogels are excellent choices for a range of pharmaceutical applications, especially in tissue engineering, drug delivery, wound treatment, and automated release systems. The prolonged, targeted, and stimuli-responsive medication absorption that hydrogels can provide improves the oral absorption and therapeutic effectiveness of pharmacological drugs while reducing systemic adverse effects. Beyond conventional drug delivery methods, hydrogels are finding increasing utility in injectable compositions, transdermal patches, ocular medication administration, and customized medicine. Furthermore, hydrogels have shown great promise in the treatment of wounds by offering conditions that retain moisture, which speeds up healing and lessens discomfort. Hydrogels are used in tissue engineering as scaffolds for tissue regeneration and cell development, providing novel approaches to the treatment of injured tissues. This study addresses the many pharmaceutical uses of hydrogels, emphasizes their benefits in contemporary treatments, and investigates the difficulties and potential paths in hydrogel-based drug delivery systems. The next generation of pharmaceutical formulations might be advanced with the continuous development of intelligent, biodegradable, and responsive hydrogels, which would also enhance patient outcomes and allow for more individualized, efficient therapies.

Keywords: Retention, Biocompatibility, Hydrogels, Biodegradable, Polymers