Innovative Discovery Studies of Anti Lungs Cancer Active Drug Substances in Medicinal Chemistry

Innovative Discovery Studies of Anti Lungs Cancer Active Drug Substances in Medicinal Chemistry

Narayanamoorthy. B

Under The Guidance of Dr. CT. Ravichandran, M.Sc., M.Phil., Ph.D., Associate Professor and Head

Department of Chemistry, Master of Philosophy in Chemistry

Arignar Anna Govt. Arts College,

Cheyyar- 604 407.

Abstract:

                                              The discovery study of anti cancer active drug substance of (2S,2′S)-2,2′-[[2,2′- Diamino-4,4′,6-trioxo-1,4,4′,6,7,7′-hexahydro-1′H,5H-5,6′-bipyrrolo[2,3-d]pyrimidine-5,5′-diyl]bis(ethylenebenzene-4,1-diylcarbonylimino)] dipentanedioic  acid was synthesized and characterized by medicinal chemistry bath way, also this product was obtained   via  the   associated with the synthesis of pemetrexed disodium was performed. The possibility of (2S,2′S)-2,2′-[[2,2′-Diamino-4,4′,6-trioxo-1,4,4′,6,7,7′-hexahydro-1′H,5H-5,6′-bipyrrolo[2,3-d]pyrimidine-5,5′-diyl]bis(ethylenebenzene-4,1-diylcarbonylimino)] dipentanedioic acid forming has been mentioned in literature, but no study on this structure has been published yet. This paper describes the development of the synthesis methods and preclinical studies for this compound and discusses their structure elucidation on the basis of NMR experiments and MS data. The identification of anti cancer drug activity of this compound by preclinical test, it should be useful for identify the new anticancer drug in pemetrexed generation.