The Study of 2-Substituted 2-Oxazolin-5-Ones with Special Aromatic Hyrdroxy Aldehydes in Dissimilar Compression to Situ Generated Compound
P Venugopal, Dr.K.B.Chandrasekhar, Dr.T.Payani, Dr.Narmada
Chemistry Department,
Javaharlal nehru Technology University Ananthapuram A.P, India
ABSTRACT:
The bioactive synthesize of 2-Substituted 2-oxazolin 4-(hydroxybenzylidene)-5-ones are the a regimented method ,the 2-Substituted 2-oxazolin-5-ones compound are one of the saturated azlactones and active reaction the compound of .2-Oxazolin-5-ones are used for the antibacterial,antifungal,antibiotics and anticancer activities recently activities the compound of α-N-Acylglycines (1) are using in situ generated processing invarious cyclising agents namely ethyl chloroformate (2), a of the condensation studies of aromatic hydroxy aldehydes 2,3and 4 (6) with 2-Substituted 2-oxazolin-5-ones (5).
The compound of p-toluene sulphonyl chloride (4)and benzene sulphonyl chloride (3) in presence of benzene are the triethylamine in dry of base. The Group of hydroxyl at 4- and 3- positions of the ring of the aldehydes aromatic are p- hydroxybenzaldehyde (6c), m-hydroxybenzaldehyde (6b)and 3-methoxybenzaldehyde4-hydroxyl group-6a), to the on the assemble 2-substituted-2-oxazolin, 4 (m-hydroxybenzylidene)-5-one (8b), 2-substituted-4(p-hydroxybenzylidene)-2-oxazolin-5-one (8c) and 2-substituted 4-(p-hydroxy-m-methoxybenzylidene)-2-oxazolin-5-one (8a), correspondingly the compounds structure as (Z)-isomers, are the Salicyl aldehyde of produces 3-N-acylaminocoumarins is one of the name of 2-hydroxy aromatic aldehyde (9) on compression with the 2-oxazolin-5-ones (5) are 2 -Substituted in the substantial purityand quality of yield. The reaction of substituted are the adduct arrangement in (E)-2-substituted 4-(o-hydroxybenzylidene-2-oxazolin-5-ones in the reaction (7), the extension of the reaction with the 1,5- range of bond of intra molecular aspects on the ring of 2-oxazolin-5-one on the group of phenolic and recyclization of subsequent led to the structure of ensuing coumarin of 3-N-acylaminocoumarins (9). It is free group of hydroxyl bearing benzylidene at 4-position in 2-oxazolin-5-ones (8) were produced. The All steps are carried out in one single flask.
Keywords: Cyclisingagents, crystallization, 3-N-Acylaminocoumarins, Synthons, 4-(Hydroxybenzylidene) Azlactones, Cyclisingagents, Substitute, in situ
