Therapeutic Significance of Licorice in Polycystic Ovary Syndrome Management

Polycystic Ovary Syndrome (PCOS) is a common endocrine and metabolic disorder affecting women of reproductive age and is characterized by insulin resistance, hyperandrogenism, irregular menstrual cycles, and ovulatory dysfunction. Conventional management of PCOS mainly includes lifestyle modification and pharmacological treatments such as metformin and anti-androgenic drugs. However, long-term use of these therapies may cause side effects, leading to increasing interest in herbal and complementary medicines. Licorice (Glycyrrhiza glabra) is a widely used medicinal plant known for its anti-androgenic, estrogen-like, anti-inflammatory, and insulin-sensitizing properties. This review highlights the potential role of licorice in the management of PCOS by summarizing its botanical profile, active constituents, traditional uses, and mechanisms of action. Studies from in vitro experiments, animal models, and human clinical trials indicate that licorice and its bioactive compounds, such as glycyrrhizin and glycyrrhetinic acid, may help reduce elevated androgen levels, improve insulin sensitivity, regulate menstrual cycles, and support ovarian function. Additionally, licorice has shown potential benefits as an adjuvant therapy when used with conventional treatments. Despite these promising findings, concerns related to dosage standardization, safety, and long-term use remain. Further well-designed clinical studies are required to establish the efficacy and safety of licorice in PCOS management.